Stephen Toulmin states that "the question 'Do neutrinos [i.e., sub-microscopic entities] exist?' acts as an invitation to 'produce a neutrino'." Why does he think doing so is particularly difficult?

Neutrinos are produced by the decay of radioactive elements, which makes studying them inherently dangerous
It isn't obvious what standards to adopt when deciding what counts as producing entities such as neutrinos
Unlike extinct animal species such as dodos which can be found in the fossil record, sub-microscopic entities don't leave tangible evidence of their existence
Since causation may or may not work in the same way at the sub-microscopic level as it does at the level of human perception, we often don't know how to produce neutrinos
All of the above